药物详细合成路线

Name	Carazolol;BM-51052
Chemical Name	1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)-2-propanol
CAS	57775-29-8
Related CAS
Formula	C18H22N2O2
Structure
Formula Weight	298.38824
Stage	未确定
Company
Activity/Mechanism
Syn. Route	1

Route 1 by condensation of 4-hydroxycarbazole (i) with epichlorohydrin (ii) by means of naoh in aqueous dioxane at 40 c to yield 4-(2,3-epoxypropoxy)carbazole (iii), followed by treatment with isopropylamine (iv) in refluxing ethanol List of intermediates No. (6r,7r)-7-[[2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino]-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (ii) [1-(4-bromobenzyl)-2-butyl-4-chloro-1h-imidazol-5-yl]methanol (iv) benzyl (2s)-2-amino-3-methylbutanoate (i) n-(8-amino-6-fluoro-5-methyl-1-oxo-1,2,3,4-tetrahydro-2-naphthalenyl)-2,2,2-trifluoroacetamide (iii) Reference 1:     weetman, d.f.; castaner, j.; carazolol. drugs fut 1977, 2, 11, 715. Reference 2:     leinert, h.; et al. (boehringer ingelheim gmbh); triyclic diphenylamines derivatives. ch 598216; de 2240599; fr 2196165; gb 1369580; jp 49056973 .

来源:药化网

作者:药化小编

摘要:本文合成路线介绍的是药物中文名卡拉洛尔；英文名Carazolol;BM-51052；CAS[57775-29-8]

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