药物详细合成路线
Name | Carazolol;BM-51052 | Chemical Name | 1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)-2-propanol | CAS | 57775-29-8 | Related CAS | | Formula | C18H22N2O2 | Structure | | Formula Weight | 298.38824 | Stage | 未确定 | Company | | Activity/Mechanism | | Syn. Route | 1 | Route 1 | by condensation of 4-hydroxycarbazole (i) with epichlorohydrin (ii) by means of naoh in aqueous dioxane at 40 c to yield 4-(2,3-epoxypropoxy)carbazole (iii), followed by treatment with isopropylamine (iv) in refluxing ethanol | | | List of intermediates | No. | (6r,7r)-7-[[2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino]-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | (ii) | [1-(4-bromobenzyl)-2-butyl-4-chloro-1h-imidazol-5-yl]methanol | (iv) | benzyl (2s)-2-amino-3-methylbutanoate | (i) | n-(8-amino-6-fluoro-5-methyl-1-oxo-1,2,3,4-tetrahydro-2-naphthalenyl)-2,2,2-trifluoroacetamide | (iii) | | Reference 1: weetman, d.f.; castaner, j.; carazolol. drugs fut 1977, 2, 11, 715. Reference 2: leinert, h.; et al. (boehringer ingelheim gmbh); triyclic diphenylamines derivatives. ch 598216; de 2240599; fr 2196165; gb 1369580; jp 49056973 . | |
来源:药化网
作者:药化小编
摘要:本文合成路线介绍的是药物中文名卡拉洛尔;英文名Carazolol;BM-51052;CAS[57775-29-8]
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