药物详细合成路线
| Name | Sofalcone | | Chemical Name | 2-[5-(3-Methyl-2-butenyloxy)-2-[3-[4-(3-methyl-2-butenyloxy)phenyl]-2(E)-propenoyl]phenoxy]acetic acid | | CAS | 64506-49-6 | | Related CAS | | | Formula | C27H30O6 | | Structure |  | | Formula Weight | 450.53655 | | Stage | 临床前 | | Company | Taisho (Originator) | | Activity/Mechanism | Antiulcer Drugs, GASTROINTESTINAL DRUGS | | Syn. Route | 1 | | Route 1 | | the reaction of 2-hydroxy-4-(3-methyl-2-butenyloxy)acetophenone (i) with ethyl bromoacetate (ii) by means of koh in acetone gives 2-ethoxycarbonylmethoxy-4-(3-methyl-2-butenyloxy)acetophenone (iii), which is then condensed with 4-(3-methyl-2-butenyloxy)benzaldehyde (iv) by means of koh in ethanol. | | |  | | List of intermediates | No. | | methyl 1-hydrazinecarbimidothioate | (i) | | [(2r,3s,4s,5r)-5-(6-amino-2-fluoro-9h-purin-9-yl)-3,4-dihydroxytetrahydro-2-furanyl]methyl diethyl phosphate | (ii) | | bromo[4-[(triisopropylsilyl)oxy]phenyl]magnesium | (iv) | | n-[(1r,2r)-2-aminocyclohexyl]-n-tritylamine; (1r,2r)-n(1)-trityl-1,2-cyclohexanediamine | (iii) | | | Reference 1: grau, m.; castaner, j.; blancafort, p.; serradell, m.n.; su-88. drugs fut 1983, 8, 6, 513. Reference 2: kyogoku, k.; hatayama, k.; yokomori, s.; sawada, j.; tanaka, i. (taisho pharmaceutical co., ltd.); 2-(carboxymethoxy)chalcones. de 2705603; es 455620; fr 2340924; gb 1523241; jp 52097950; us 4085135 . |
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来源:药化网
作者:药化小编
摘要:本文合成路线介绍的是药物中文名索法酮；英文名Sofalcone；CAS[64506-49-6]
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