药物详细合成路线
| Name | Dimaprit | | Chemical Name | 1-(Amidinosulfanyl)-3-(dimethylamino)propane | | CAS | 65119-89-3 | | Related CAS | | | Formula | C6H15N3S | | Structure |  | | Formula Weight | 161.27055 | | Stage | 未确定 | | Company | | | Activity/Mechanism | Histamine H2 Receptor Agonists, Nitric Oxide Synthase Inhibitors | | Syn. Route | 1 | | Route 1 | | by condensation of 3-dimethylaminopropyl chloride (i) with thiourea (ii) in refluxing ethanol. | | |  | | List of intermediates | No. | | methyl (1s,3as,4s,5s,7as)-4-(cyanomethyl)-7a-methyl-5-[(1r,3r,6r)-3-methyl-2-oxo-7-oxabicyclo[4.1.0]hept-3-yl]octahydro-1h-indene-1-carboxylate | (ii) | | diethyl 2,2,5,5-tetramethylhexanedioate | (i) | | | Reference 1: weetman, d.f.; castaner, j.; dimaprit. drugs fut 1978, 3, 4, 273. Reference 2: kartinos, n.j. (baxter international inc.); gamma-dimethylaminopropyl isothiourea and acid addition salts thereof. us 3116327 . |
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