药物详细合成路线

Name	Dimaprit
Chemical Name	1-(Amidinosulfanyl)-3-(dimethylamino)propane
CAS	65119-89-3
Related CAS
Formula	C6H15N3S
Structure
Formula Weight	161.27055
Stage	未确定
Company
Activity/Mechanism	Histamine H2 Receptor Agonists, Nitric Oxide Synthase Inhibitors
Syn. Route	1

Route 1 by condensation of 3-dimethylaminopropyl chloride (i) with thiourea (ii) in refluxing ethanol. List of intermediates No. methyl (1s,3as,4s,5s,7as)-4-(cyanomethyl)-7a-methyl-5-[(1r,3r,6r)-3-methyl-2-oxo-7-oxabicyclo[4.1.0]hept-3-yl]octahydro-1h-indene-1-carboxylate (ii) diethyl 2,2,5,5-tetramethylhexanedioate (i) Reference 1:     weetman, d.f.; castaner, j.; dimaprit. drugs fut 1978, 3, 4, 273. Reference 2:     kartinos, n.j. (baxter international inc.); gamma-dimethylaminopropyl isothiourea and acid addition salts thereof. us 3116327 .

来源:药化网

作者:药化小编

摘要:本文合成路线介绍的是药物中文名；英文名Dimaprit；CAS[65119-89-3]

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