药物详细合成路线

Name	Impromidine hydrochloride;SK&F-92676-A3
Chemical Name	N-[2-(1H-Imidazol-4-ylmethylsulfanyl)ethyl]-N-[3-(5-methyl-1H-imidazol-4-yl)propyl]guanidine trihydrochloride
CAS	65573-02-6
Related CAS	55273-05-7 (free base)
Formula	C14H26Cl3N7S
Structure
Formula Weight	430.83322
Stage	未确定
Company
Activity/Mechanism
Syn. Route	1

Route 1 the reaction of n-[2-[(5-methyl-4-imidazolyl)methylthio]ethyl]thiourea (i) with methyl iodide in methanol gives the corresponding thiouronium iodide (ii), which is converted into the sulfate by treatment with ira 401 ion-exchange resin. finally, this sulfate is condensed with 4-(3-aminopropyl)imizadole (iii) in refluxing water. List of intermediates No. 4-[(3s,4r)-7-methoxy-2-oxo-3-phenyl-3,4-dihydro-2h-chromen-4-yl]phenyl acetate (iii) ethyl 4-(3-bromopropoxy)-3-methyl-1-benzofuran-2-carboxylate (i) 3-chloro-4-hydroxybenzoic acid methyl ester; methyl 3-chloro-4-hydroxybenzoate (ii) Reference 1:     durant, g.j.; et al.; us 4013659 . Reference 2:     serradell, m.n.; hopkins, s.j.; blancafort, p.; castaner, j.; impromidine. drugs fut 1979, 4, 9, 647.

来源:药化网

作者:药化小编

摘要:本文合成路线介绍的是药物中文名；英文名Impromidine hydrochloride;SK&F-92676-A3；CAS[65573-02-6]

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