药物详细合成路线
| Name | Impromidine hydrochloride;SK&F-92676-A3 | | Chemical Name | N-[2-(1H-Imidazol-4-ylmethylsulfanyl)ethyl]-N-[3-(5-methyl-1H-imidazol-4-yl)propyl]guanidine trihydrochloride | | CAS | 65573-02-6 | | Related CAS | 55273-05-7 (free base) | | Formula | C14H26Cl3N7S | | Structure |  | | Formula Weight | 430.83322 | | Stage | 未确定 | | Company | | | Activity/Mechanism | | | Syn. Route | 1 | | Route 1 | | the reaction of n-[2-[(5-methyl-4-imidazolyl)methylthio]ethyl]thiourea (i) with methyl iodide in methanol gives the corresponding thiouronium iodide (ii), which is converted into the sulfate by treatment with ira 401 ion-exchange resin. finally, this sulfate is condensed with 4-(3-aminopropyl)imizadole (iii) in refluxing water. | | |  | | List of intermediates | No. | | 4-[(3s,4r)-7-methoxy-2-oxo-3-phenyl-3,4-dihydro-2h-chromen-4-yl]phenyl acetate | (iii) | | ethyl 4-(3-bromopropoxy)-3-methyl-1-benzofuran-2-carboxylate | (i) | | 3-chloro-4-hydroxybenzoic acid methyl ester; methyl 3-chloro-4-hydroxybenzoate | (ii) | | | Reference 1: durant, g.j.; et al.; us 4013659 . Reference 2: serradell, m.n.; hopkins, s.j.; blancafort, p.; castaner, j.; impromidine. drugs fut 1979, 4, 9, 647. |
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来源:药化网
作者:药化小编
摘要:本文合成路线介绍的是药物中文名；英文名Impromidine hydrochloride;SK&F-92676-A3；CAS[65573-02-6]
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