药物详细合成路线

Name	Tolciclate;K-9147
Chemical Name	N-Methyl-N-(3-methylphenyl)carbamothioic acid O-(1,2,3,4-tetrahydro-1,4-methanonaphthalen-6-yl) ester
CAS	50838-36-3
Related CAS
Formula	C20H21NOS
Structure
Formula Weight	323.46047
Stage	未确定
Company
Activity/Mechanism	Antifungal Agents, ANTIINFECTIVE THERAPY
Syn. Route	1

Route 1 compound can be prepared in two different ways both starting from sodium 1,4-methano-1,2,3,4-tetrahydro-6-naphthoxide (i):1) the reaction of (i) with thiophosgene in chloroform gives o-(1,4-methano-1,2,3,4-tetrahydro-6-naphthyl)chlorothioformiate (ii), n(20 c)(d) = 1.5930, which is then condensed with n-methyl-m-toluidine in the same solvent.2) the condensation of (i) with n-methyl-n-(m-tolyl)thiocarbamoyl chloride (iii) in acetone. List of intermediates No. (3r)-6-bromo-3-(dicyclobutylamino)-8-fluoro-3,4-dihydro-2h-chromene-5-carboxylic acid (iii) 2-benzyl 4-ethyl 4,8,8-trimethyl-6,10-dioxa-2-azaspiro[4.5]decane-2,4-dicarboxylate (i) ethyl 2-benzyl-4,8,8-trimethyl-6,10-dioxa-2-azaspiro[4.5]decane-4-carboxylate (ii) (2-benzyl-4,8,8-trimethyl-6,10-dioxa-2-azaspiro[4.5]dec-4-yl)methanol (iv) Reference 1:     castaner, j.; de angelis, l.; tolciclate. drugs fut 1976, 1, 11, 543. Reference 2:     melloni, p.; et al.; tetrahydro-2-naphthyl ester derivatives of tinonocarbanilic acids. de 2313845; fr 2181835; gb 1364407; jp 49005955; us 3855263 .

来源:药化网

作者:药化小编

摘要:本文合成路线介绍的是药物中文名；英文名Tolciclate;K-9147；CAS[50838-36-3]

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