药物详细合成路线
| Name | Suplatast tosilate;IPD-1151T;IPD;MPD | | Chemical Name | (±)-2-[N-[4-(3-Ethoxy-2-hydroxypropoxy)phenyl]carbamoyl]ethyldimethylsulfonium p-toluenesulfonate | | CAS | 94055-76-2 | | Related CAS | | | Formula | C23H33NO7S2 | | Structure |  | | Formula Weight | 499.64996 | | Stage | 上市-1995 | | Company | Taiho (Originator), Yamanouchi (Licensee) | | Activity/Mechanism | Antiallergy/Antiasthmatic Drugs, Asthma Therapy, Atopic Dermatitis, Agents for, DERMATOLOGIC DRUGS, Drugs for Allergic Rhinitis, RENAL-UROLOGIC DRUGS, RESPIRATORY DRUGS, Treatment of Upper Respiratory Tract Disorders, Urologic Drugs, Mediator Release Inhibitors | | Syn. Route | 1 | | Route 1 | | the condensation of 3-(methylmercapto)propionyl chloride (i) with 4-(3-ethoxy-2 hydroxypropoxy) aniline (ii) by means of triethylamine in dmf gives the corresponding amide (iii), which is then treated with methyl p-toluenesulfonate (iv) in dichloromethane. | | |  | | List of intermediates | No. | | 2-[(3-bromo-4,5-dimethoxyphenyl)(hydroxy)methyl]-6-chloro-n-methylbenzamide | (i) | | 3-(3-bromo-4,5-dimethoxyphenyl)-7-chloro-2-benzofuran-1(3h)-one | (ii) | | 3-(3-bromo-4,5-dimethoxyphenyl)-7-chloro-1,3-dihydro-2-benzofuran-1-ol | (iii) | | dimethyl 1-(3-bromo-4,5-dimethoxyphenyl)-5-chloro-2,3-naphthalenedicarboxylate | (iv) | | | Reference 1: hori, m.; matsuura, n.; ueda, s.; yamawaki, i.; yasumoto, m.; tada, y.; koda, a. (taiho pharmaceutical co., ltd.); sulfonium cpds., processes for preparing the cpds. and pharmacological compsns. containing the same. ch 659066; de 3408708; fr 2542312; gb 2137986; jp 1984167564; jp 1984170062; jp 1985152459; us 4556737 . Reference 2: prous, j.; castaner, j.; ipd-1151t. drugs fut 1988, 13, 11, 952. |
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来源:药化网
作者:药化小编
摘要:本文合成路线介绍的是药物中文名甲磺司特；英文名Suplatast tosilate;IPD-1151T;IPD;MPD；CAS[94055-76-2]
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